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Cyclosporine Soft Gel Capsules

Cyclosporine Soft Gel Capsules
Cyclosporine Soft Gel Capsules
Price And Quantity
  • Box/Boxes
  • 300
  • Box/Boxes
  • 74 INR
    Product Specifications
    • General Medicines
    • glycerin, glyceryl caprylate
    • Capsules
    • Adults
    • Cool and Dry Place
    Product Description
    Cyclosporine lowers your body's immune system. The immune system helps your body fight infections. The immune system can also fight or "reject" a transplanted organ such as a liver or kidney. This is because the immune system treats the new organ as an invader.Cyclosporine is used to prevent organ rejection after a kidney, heart, or liver transplant. Cyclosporine is also used to treat severe psoriasis or severe rheumatoid arthritis.

    Pharmacology:

    Pharmacodynamic Properties Of Cyclosporine
    Used in immunosuppression for prophylactic treatment of organ transplants, cyclosporine exerts specific and reversible inhibition of immunocompetent lymphocytes in the G0-or G1-phase of the cell cycle. T-lymphocytes are preferentially inhibited. The T1-helper cell is the main target, although the T1-suppressor cell may also be suppressed. Sandimmune (cyclosporine) also inhibits lymphokine production and release including interleukin-2.
    Pharmacokinetic Properties Of Cyclosporine
    • Absorption:
      The absorption of cyclosporine from the gastrointestinal tract is incomplete and variable. The extent of absorption is dependent on the individual patient, the patient population, and the formulation.
    • Protein Binding:
      In the plasma, approximately 90% is bound to proteins, primarily lipoproteins. In blood, the distribution is concentration dependent. Approximately 33% to 47% is in plasma, 4% to 9% in lymphocytes, 5% to 12% in granulocytes, and 41% to 58% in erythrocytes.
    • Metabolism:
      Hepatic, extensively metabolized by the cytochrome P450 3A enzyme system in the liver. It is also metabolized in the gastrointestinal tract and kidney to a lesser degree. The metabolites are significantly less potent than the parent compound. The major metabolites (M1, M9, and M4N) result from oxidation at the 1-beta, 9-gamma, and 4-N-demethylated positions, respectively.
    • Route Of Elimination:
      Elimination is primarily biliary with only 6% of the dose (parent drug and metabolites) excreted in the urine. Only 0.1% of the dose is excreted in the urine as unchanged drug.
    Pregnancy & Lactation
    Pregnancy Pregnant women receiving immunosuppressive therapies after transplantation, including cyclosporin and cyclosporin-containing regimens, are at risk of premature delivery.
    Breast-Feeding Cyclosporin passes into breast milk. The ethanol content of the Neoral formulations should also be taken into account in women who are breast-feeding
    Contraindications
    Hypersensitivity to the active substance or to any of the excipients.
    Side Effects
    Very rare but the common side effects are:
    ●Shaking
    ●Headache
    ●Dizziness
    ●Unusual growth of body hair,
    ●Nausea/vomiting
    ●Diarrhea
    ●Stomach upset

    Trade Information
    • Cash in Advance (CID), Cash Advance (CA)
    • 300 Per Month
    • 1 Months
    • Yes
    • Sample costs shipping and taxes has to be paid by the buyer
    • Africa, Middle East, Western Europe, Eastern Europe, South America, North America, Central America, Australia, Asia
    • All India
    Contact Us

    Plot No. 34, Bholabhai Nagar Chanod, GIDC, Silvassa Road, Vapi INA, Gujarat, 396195, India
    Phone :+918061881475