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Sildenafil Citrate Soft Gelatin Capsules

Sildenafil Citrate Soft Gelatin Capsules
Sildenafil Citrate Soft Gelatin Capsules
Price And Quantity
  • Box/Boxes
  • 300
  • Box/Boxes
  • 74 INR
    Product Specifications
    • 98%
    • General Drugs
    • Capsules
    • Adult
    • Dry Place
    Product Description
    Sildenafil (as citrate) belongs to a group of medicines called phosphodiesterase type 5 (PDE5) inhibitors. Sildenafil citrate is designated chemically as 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate and has the following structural formula:Sildenafil is an oral therapy for erectile dysfunction. With sexual stimulation, it restores impaired erectile function by increasing blood flow to the penis. It is a drug which is formulated to immediately cure impotency of male organ in significantly short span of time. This is possible due to the effective and active component Sildenafil which is present in the capsule in gel form encapsulated in gelatin capsule- cover.

    Indications:
    It is indicated for the treatment of erectile dysfunction.

    Pharmacology:

    Pharmacological Properties:
    Sildenafil protects cyclic guanosine monophosphate (cGMP) from degradation by cGMP-specific phosphodiesterase type 5(PDE5) in the corpus cavernosum. Nitric oxide(NO) in the corpus cavernosum of the penis binds to guanylate cyclase receptors, which results in increased levels of cGMP, leading to smooth muscle relaxation (vasodilation). This smooth muscle relaxation leads to vasodilation and increased inflow of blood into the spongy tissue of the penis, causing an erection.Sildenafil is a potent and selective inhibitor of cGMP-specific phosphodiesterase type 5(PDE5), which is responsible for degradation of cGMP in the corpus cavernosum.Without sexual stimulation, and therefore lack of activation of the NO/cGMP system, sildenafil should not cause an erection.

    Pharmacokinetics Properties:
    ABSORPTION:Sildenafil is rapidly absorbed. Maximum observed plasma concentrations are reached within 30 to 120 minutes (median 60 minutes) of oral dosing in the fasted state. The mean absolute oral bioavailability is 41% (range 25-63%). After oral dosing of sildenafil AUC and Cmax increase in proportion with dose over the recommended dose range (25-100 mg).When sildenafil is taken with food, the rate of absorption is reduced with a mean delay in tmax of 60 minutes and a mean reduction in Cmax of 29%.
    DISTRIBUTION:The mean steady state volume of distribution (Vd) for sildenafil is 105 L, indicating distribution into the tissues. After a single oral dose of 100 mg, the mean maximum total plasma concentration of sildenafil is approximately 440 ng/mL (CV 40%). In healthy volunteers receiving sildenafil (100 mg single dose), less than 0.0002% (average 188 ng) of the administered dose was present in ejaculate 90 minutes after dosing.
    BIOTRANSFORMATION:Sildenafil is cleared predominantly by the CYP3A4 (major route) and CYP2C9 (minor route) hepatic microsomal isoenzymes. The major circulating metabolite results from N-demethylation of sildenafil. This metabolite has a phosphodiesterase selectivity profile similar to sildenafil and an in vitro potency for PDE5 approximately 50% that of the parent drug. Plasma concentrations of this metabolite are approximately 40% of those seen for sildenafil. The N-desmethyl metabolite is further metabolised, with a terminal half-life of approximately 4 h.
    ELIMINATION:The total body clearance of sildenafil is 41 L/h with a resultant terminal phase half-life of 3-5 h. After either oral or intravenous administration, sildenafil is excreted as metabolites predominantly in the faeces (approximately 80% of administered oral dose) and to a lesser extent in the urine (approximately 13% of administered oral dose).

    Interactions:
    Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.
    Care should be exercised by people who are also taking protease inhibitors for the treatment of HIV infection. Protease inhibitors inhibit the metabolism of sildenafil, effectively multiplying the plasma levels of sildenafil, increasing the incidence and severity of side effects.
    Those using protease inhibitors are recommended to limit their use of sildenafil to no more than one 25 mg dose every 48 hours. Other drugs that interfere with the metabolism of sildenafil include erythromycin and cimetidine, both of which can also lead to prolonged plasma half-life levels. The use of sildenafil and an a1 blocker (typically prescribed for hypertension or for urologic conditions, such as benign prostatic hypertrophy) at the same time may lead to low blood pressure, but this effect does not occur if they are taken at least 4 hours apart.

    Precautions & Warnings:
    Talk to your doctor, pharmacist or nurse before taking this medication:
    • If you have sickle cell anaemia (an abnormality of red blood cells), leukaemia (cancer of blood cells), multiple myeloma (cancer of bone marrow).
    • If you have a deformity of your penis or Peyronie's Disease.
    • Nitrate containing pills should be avoided with the consumption of this medication as their combination could lead to severe health complications in the person. This is because, nitrate pills are used in the treatment of chest pain and troubles relating to heart.
    • If you currently have a stomach ulcer, or a bleeding problem (such as haemophilia).
    • If you experience sudden decrease or loss of vision, stop taking this medication and contact your doctor immediately.
    • You should not use this medicine with any other oral or local treatments for erectile dysfunction.
    • You should not use this medicine with treatments for pulmonary arterial hypertension (PAH) containing sildenafil or any other PDE5 inhibitors.
    • You should not take this if you do not have erectile dysfunction.
    • You should not take this if you are a woman, children and teenager
    • The medication should not be consumed on a daily basis as it can lead to a habitual action within the person. Thus, this kind of consumption could lead to addiction of this medication in the person. Thus, this can bring out adverse side effects over the person.
    • If you have known hypersensitivity to sildenafil
    • Sildenafil is not indicated for use by women.
    • There are no adequate and well-controlled studies in pregnant or breastfeeding women.

    Side Effects:
    The most common adverse effects of sildenafil:
    • Headache
    • Flushing
    • Indigestion
    • Nasal congestion
    • Impaired vision
    • Blurred vision
    Trade Information
    • Cash in Advance (CID), Cash Advance (CA)
    • 300 Per Month
    • 1 Months
    • Yes
    • Sample costs shipping and taxes has to be paid by the buyer
    • Africa, Middle East, Western Europe, Eastern Europe, South America, North America, Central America, Australia, Asia
    • All India
    Contact Us

    Plot No. 34, Bholabhai Nagar Chanod, GIDC, Silvassa Road, Vapi INA, Gujarat, 396195, India
    Phone :+918045803310